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Beyond this window, oxidation converts reduced glutathione (GSH) to its inactive form (GSSG) at accelerating rates, stripping the molecule of its electron-donating antioxidant capacity

Intriguingly, CPKS exhibits no toxicity even after 48 h of incubation, indicating its potential as a safe and effective theranostic agent

Proc Natl Acad Sci USA 101:1001210017 Wu XJ, Zhang ML, Cui XY, Gao F, He Q, Li XJ, Zhang JW, Fawcett JP, Gu JK (2012) Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat

While mammals carry eight genes encoding canonical GPX, proteins such as GST [26] and peroxiredoxin [27] also show GSH-dependent peroxidase activity to some extent