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hepatic macrophages, Kupffer cells, hepatic neutrophils, produce and release large quantities of ROS such as superoxide anion, hydrogen peroxide, nitric oxide, and their derivatives, which target the surrounding tissue and cause oxidative stress intra- or extracelluarly (Bautista et al

The cysteine-GSH-GPX4 axis inhibits LOX activation by maintaining a reduced intracellular redox environment [42, 163]

Enrichment analysis of genes expressed significantly differently in PD patients and controls Differentially expressed genes (DEGs) between PD patients and controls were obtained by analyzing gene expression data from GEO with access ID GSE8397 44,164 (Supplementary Table 6)

Circulating insulin-like growth factor 1-related biomarkers and risk of lethal prostate cancer