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Acute cigarette smoke exposure reduces clot lysisassociation between altered fibrin architecture and the response to t-PA

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PMID: 31491072 What They Did : Collected information (chart review and standardized interview) and performed descriptive analysis on patient demographics, signs and symptoms, and management of EVALI in a case series of reports to the Wisconsin Department of Health Services (WDHS) and the Illinois Department of Public Health (IDPH) of patients recent e-cigarette use with pulmonary infiltrates in whom alternate etiologies had been ruled out Conducted syndromic surveillance of emergency department visits for severe unexplained respiratory symptoms Inclusion : Case Series : Cases (n=98) reported to the WDHS and the IDPH of respiratory illness with use of an e-cigarette or dabbing in the 90 days preceding symptom onset Pulmonary infiltrate on imaging and absence of other primary etiologies for respiratory symptoms (e.g., suspected secondary pneumonia meeting the other criteria would be included as a probable case) Syndromic Evaluation : 14 to 30 years of age ED visit between January 1, 2018 through August 15, 2019 in affected counties in Illinois Presenting with severe respiratory symptoms with initial pulse oximetry of 96% or less (or not recorded) who were admitted or not discharged home and with no known etiology upon admission Exclusion Criteria: Evidence of alternative primary diagnoses for respiratory symptoms Results: In the syndrome surveillance portion of the study, there were twice as many patients presenting for severe respiratory illness in the time frame studied when compared to the previous year