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Biomedicines 2023,11, 2226 13 of 18 Author Contributions: Conceptualization: H.R.M., B.A.F., M.B

Clinically, many late-onset MADD patients respond dramatically to high-dose riboflavin (100400 mg/day), confirming residual enzyme function amenable to cofactor restorationclassifying MADD as a prototype FAD-responsive metabolic myopathy (70)