glutathione spin trap Trapping - an overview Electron paramagnetic resonance and spin

People with MTHFR mutation have an increased risk of developing mental health issues, fatigue, cardiovascular problems, migraines, certain types of cancer, and neural tube defects in fetuses

Abbreviations ACTH: adrenocorticotropic hormone CF: chronic fatigue CFS: chronic fatigue syndrome CMI: cell-mediated immune CNS: central nervous system CRH: corticotropin-releasing hormone CVD: cardiovascular disease DISC1: disrupted-in-schizophrenia 1 EBV: Epstein-Barr virus HHV: human herpesvirus HPA: hypothalamic-pituitary-adrenal IBS: irritable bowel syndrome IL: interleukin IL-1RA: IL-1 receptor antagonist LPS: lipopolysaccharide MDA: malondialdehyde ME: myalgic encephalomyelitis NF: nuclear factor O&NS: oxidative and nitrosative stress PEM: post-exertion malaise lasting more than 24 h PGs: prostaglandins PUFAs: polyunsaturated fatty acids RNS: reactive nitrogen species ROS: reactive oxygen species SF-36: 36-item short-form health survey SNS: sympathetic nervous system TDO: tryptophan 2,3-dioxygenase TGF: transforming growth factor Th: T helper TNF: tumor necrosis factor

Ethics declarations Competing interests The authors declare that they have no competing interests

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