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Description

The Nrf2 induction prevents ferroptosis in Friedreichs ataxia

Given the significant reduction in intracellular GSH, and induction of its canonically partnering stress response, we asked whether this impacted intracellular selenoprotein abundance in the CNS

F.MappP

Collectively, these Pharmacophore characteristics support the hypothesis that NAC can act as a molecular stabilizer, counteracting Crystallin unfolding and aggregation processes that drive age-related lens opacity, thereby positioning NAC as a promising therapeutic candidate for anti-cataract intervention 106