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Longer than that and the fatigue and neuro symptoms start up again

Jack Khattar, president & CEO of Supernus, said the company remain[s] committed to bringing SPN-830 to the market and will work with the FDA to address the issues identified in the CRL and resubmit the NDA

In addition, excess vitamin B12 that is not absorbed in the intestine can change the gut microbiome composition and may cause an overgrowth of intestinal bacteria