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the National Natural Science Foundation of China (NSFC), Budget-Based Project (Grant No

Glucose metabolism has been shown to modulate the effector function of T H 17 cells by controlling a metabolic-transcriptional network, with Acly serving as a key rate-limiting mediator generating acetyl-CoA and dictating T H 17 cell pathogenicity 21 , while restraining the development of FOXP3 + T regs 74

Past history revealed hospitalization for investigation of cyanosis at 9 months of age but no diagnosis was made at this time or during several other clinical consultations over the intervening years