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Description

Academic Press: New York, 1994

Aside from autophagic vesicles, icaritin degrades mitochondrial proteins (e.g., MNF1, MNF2, HSP60, TOM20, and TiM23) in liver cancer (SK-Hep1) cells [696]

This flood of endotoxins is noxious (harmful) and causes the kidneys and liver to work overtime to try and remove them which causes worsening of symptoms in patients