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Most retinal optogenetics approaches depend on blue light irradiation to activate the photoswitch, during which relatively strong phototoxicity may damage corneal and retinal tissues

GSH cannot be administered directly because two pharmaceutical problems have been observed: poor bioavailability with oral administration, and a short half-life (2 min) with intravenous administration [54]

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8.1 Gene modification of MSCs Genetic modification of mesenchymal stem cells (MSCs) using viral or non-viral vectors can induce the overexpression of functional proteins and soluble factors, thereby enhancing stemness, differentiation, migration and homing capabilities, immunomodulation, and other repair-related functions ( in vitro and in vivo ), and improving their resistance to harsh microenvironments and apoptosis