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Currently, the top-down approach has not been applied to oleaginous fungi and will not be discussed

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exemplary insulin analogs include, without limitation, insulin lispro, insulin PEGIispro, the insulin derivative A14E, B25H, B29K(N(eps)octadecanedioyl-gGlu-OEG-OEG), desB30 human insulin (see, e.g., US 2014/0056953 A1), insulin aspart, insulin glulisine, insulin glargine, insulin detemir, NPH insulin, insulin degludec, or the insulin analogs/derivatives described in US 2014/0056953 A1 , which is incorporated herein by reference, particularly each one of the insulin analogs/derivatives described in paragraphs [0225] to [0332] of US 2014/0056953 A1 )