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TMAO can drive mouse macrophage polarization in NLRP3 inflammasome-dependent manner and influence the course of the inflammatory response [17]

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Although rare in developed countries, pellagra remains endemic in poorer regions, with risk factors including low socioeconomic status, alcoholism, anorexia nervosa, cancer, and malabsorptive disorders, such as Crohns disease, as well as the use of some specific medications such as immunosuppressive and anti-tuberculosis drugs (54)

These may include: Mild gastrointestinal issues: Some individuals may experience minor digestive discomfort, such as nausea or diarrhea, especially when using higher doses