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ROS-induced activation of HIF-1 in a murine model of mammary cancer activated several genes required for efficient tumor growth and lung metastasis

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Thus, manipulation of trained immunity (e.g., exogenously by administration of defined microbial products) is a potential way to influence the outcomes of inflammation and infection

CJC-1295 with DAC Side Effects & Safety Phase 1 data described CJC-1295 with DAC as relatively well tolerated at lower dose ranges, with adverse events increasing at higher exposure