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While serotonins exact role in depression is still being debated, low serotonin levels have traditionally been linked to symptoms such as sadness, low energy, and irritability all of which are often seen in people with major depressive disorder

ACTH is a peptide hormone produced by the anterior pituitary that primarily stimulates cortisol production from the adrenal cortex, but fragments of ACTH (particularly the N-terminal fragments) have been recognized since the 1970s to possess neurotrophic and cognitive-enhancing properties independent of their effects on the adrenal cortex

doi: 10.1034/j.1399-3003.2000.16b12.x

This helps to reduce the risk of mislabeling or underdosing