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Once the glucose concentration rises, it binds to glucosesensitive receptors on the neurons of the hypothalamic nuclei, triggering a series of intracellular signal transduction processes, thus enhancing the discharge frequency of these nuclei

Impaired homocysteine metabolism-mediated moderate hyperhomocysteinemia (caused by folate deficiency, vitamin B 6 deficiency, or by methionine excess) might thus have primarily pro-oxidant effects resulting from an altered extra- and intracellular redox potential that can affect essential vascular functions

It achieves this by impairing the bodys antioxidant defense systems and producing reactive oxygen species (ROS), including hydrogen peroxide and superoxide radicals

To view a copy of this licence, visit About this article Cite this article Prajapathi, S., Pradhan, A., Mohta, A