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2 Another common SNP in the MTHFR gene, known as A1298C, involves the replacement of an adenine (A) with a cytosine (C)

Skin biopsy is also used for diagnosing peripheral neuropathy on the basis of intraepidermal nerve fiber density (IENFD), while it is impractical for monitoring symptom progression or assessing treatment efficacy in clinical settings (28, 89)