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These risks should be weighed against the benefits of treatment

Other oxidation products arising from the interaction of peroxynitrite with guanine include imidazolone and oxazolone

These results align SAXS data with the observed flexibility in the hOGA cryo-EM data, corroborating the conclusion that the pHAT domains in hOGA adopt multiple conformations in solution, breaking the expected C2 symmetry and generating asymmetric dimers