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A 250 mcg dose works the same whether it came from 5 units of concentrated solution or 25 units of dilute solution

Approach [edit] The common feature of all these routine screening procedures is that the primary analysis is for indicator organisms rather than the pathogens that might cause concern

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default