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125 CS NPs (CS-NPs) have emerged as a promising platform for targeted colonic delivery of therapeutic peptides, largely due to their strong mucoadhesive interactions with the negatively charged mucin layer

However, the early mechanisms underlying such alterations remain to be elucidated

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The increase in GSH and reduction of oxidative stress biomarkers in blood and tissues reflect reduction of oxidative stress levels in tissues of mice supplemented with VD+LC compared with tissues of mice supplemented with VD alone