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Abbreviations ACP1 - acid phosphatase CAT - catalase FMN - flavin mononucleotide GPX - glutathione peroxidase GSH - plasma reduced glutathione GSSG - oxidised glutathione MHR - methemoglobin reductase SOD - Zn/Cu superoxide dismutase TMR - transmembrane reductase of ferricyanide Methemoglobin reductase (MHR) is an erythrocyte cytosolic system responsible for reactivating haemoglobin's ability to transport oxygen after it has been converted into methemoglobin by reactive oxygen species (Board & Pidcock, 1981

Conversely, FDX1 causes the destabilization of Fe-S cluster proteins

5 MichaelisMenten-Kinetics of Pt GSTF8 with flavan-3,3,4-triol (4)

These nanoparticles exert antitumor activity through the combined effects of erastin-induced ferroptosis and the Fenton reaction, both of which contribute to increased ferroptosis [159]