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These mechanisms involve modifications to the membranes lipid bilayer structure, the creation of membrane pores that impair barrier function, a decrease in membrane thickness, and alterations in permeability ( Lipid peroxidation serves as a crucial mechanism in ferroptosis, and its occurrence within the bone microenvironment significantly contributes to cellular ferroptosis, thereby impacting bone health

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With the unclamping, the tissue reperfusion occurs, determining the brusque arreval of oxygen and nutriens to the tissue, with a meaninful encrease of free radicals, extreme important phenomenon, mainly during the first 60 to 90 seconds, because it damages the reperfused area, provoking micro-heart attacks (Haliwell and Gutteridge, 1989)

2) Inflammation of the brain and vascular leak shown by an MRI finding called FLAIR (fluid attenuated inversion recovery) showing multiple white spots on the MRI