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Br J Cancer (2010) 102(12):174652

As previously mentioned, examples of longevity resulting from disruption of the GH/IGF-1 and/or insulin signaling pathway are mainly derived from early life manipulations 6,17,18 , whereas brief exposure to GH (and IGF-1) treatment early in development is sufficient to partially abrogate the exceptional longevity of Ames Dwarf mice 20