interaction of haloacetonitriles with glutathione and glutathione-s-transferase Induce Structure-Related Cellular Toxicity Through Distinct Proteome Thiol Reaction Mechanisms The role of glutathione-S-transferase in

P.TrottaF.KushwahV.DevasariN.SinghC.SureshS.et al (2016)

These cytokines not only amplify local inflammation but also further disrupt the System Xc GSHGPX4 axis and upregulate ACSL4 in neighboring tubular cells, creating a ferroptosis-inflammatory cascade that expands tubular injury

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Additionally, over-fermentation can lead to an increase of alcohol content, which may be undesirable 72