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Likewise, Prx5, the last identified member of the six mammalian Prxs (Knoops et al., 2011), is widely expressed in tissues but it is not exclusively located in mitochondria

To limit potentially life-threatening depletion of intracellular antioxidant/GSH stores, epithelial cells have developed numerous compensatory pathways, including the cystine-glutamate antiporter (SLC7A11), which critically maintains de novo GSH biosynthesis by increasing intracellular cystine levels (9)

Although no direct microbiome data are currently available for sebaceous neoplasms, the established role of the sebaceous gland in shaping skin microbial communities and the growing evidence of tumormicrobiome interactions suggest that sebaceous neoplasms are likely to harbor distinctive microbial associations

Supplementing with glutathione protects against chronic illness, supports liver health, and reduces insulin resistance