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(2) For a Part D rebatable drug with a payment amount benchmark period identified under paragraphs (c)(2) through (5) of this section, CMS will calculate the benchmark period manufacturer price as the sum of the following: (i) The product of (A) The AMP reported for the calendar quarter beginning January of the payment amount benchmark period

For example, in a classic peritoneal metastasis model of human ovarian cancer, researchers delivered daily intraperitoneal administration at 20 mg/kg/d of the product and found that it effectively inhibited the distant metastasis and rapid proliferation of HeyA8 ovarian cancer cells

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17 Screening should be considered in patients with risk factors, and diagnostic testing should be considered in those with suspected clinical manifestations