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This rarely happens with proper technique

Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, et al .: Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study

While that may sound destabilizing, it points to a conformational shift in DNA duplex architecture that could facilitate transcription while preventing hardening of the genome that often accompanies age and oxidative stress [37]

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