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Elevated NQO1 expression in ovarian cancer has been shown to confer resistance to quinone-based chemotherapeutics and promote tumor survival, highlighting the dual role of NRF2 in cytoprotection and oncogenic adaptation ( in vitro and in vivo ( Heme oxygenase-1 HMOX1 is a 32kDa key metabolic enzyme involved in the mammalian stress response ( + ), and biliverdin (BV) ( The NRF2 also targets HMOX1 and breaks it down into beneficial products, and protects against various pathologies

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No two people are the same, and studies are still being carried out to find links between the MTHFR polymorphism and potential issues