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85 OhtsukaC.SasakiM.KonnoK.KatoK.TakahashiJ.YamashitaF.et al (2014)

The histopathology slides were independently examined and scored by two authors of the current manuscript separately, then their results were compared and alignments were carried out

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Transdermal microneedles loaded with allopurinol achieve sustained urate-lowering effects by controlling drug release kinetics while minimizing gastrointestinal side effects observed with oral formulations ( 4 nanoflowers, coupled with hyaluronic acid microneedles, enhance enzyme stability and catalytic activity, effectively reducing serum uric acid levels by 30% in murine models (Hao et al., 2019)