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An early study with schizophrenia patients reported decreased prefrontal D1R compared with healthy control subjects revealed by PET [68]

Regular/moderate exercise has been shown to enhance antioxidant defense by incrementing the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD), GPx, and catalase (Miyata et al., 2008)

However, other models (such as viral hepatitis) not summarized in this paper should be treated with caution

It will depend on the ability to connect multiple sources of evidence, including: Clinical trial data Real-world clinical data Patient-reported outcomes Biomarker and genomic information Healthcare utilization data Digital health technologies The goal is not to replace randomized clinical trials but to complement them, creating a more complete picture of how therapies perform in real-world healthcare settings