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Although immune dysfunction is clear in ME/CFS, further studies using defined cohorts, standardised assays, and new technologies are required to determine specific patterns (488), contradicting the hypothesis that ME/CFS could be caused by a clearance failure of the pathogenic microbe (99, 107)

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31 These phenomena show that the oral microecosystem is significant in the pathogenesis of COPD based on the stimulation of inflammation and the promotion of lung injury