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AMP-activated protein kinase (AMPK), a sensor of cellular energy status, plays an energy stress-mediated protective role against ferroptosis ( Figure 1 The Potential Role of Ferroptosis in Lupus Immunity Most immune cell types are implicated in SLE pathogenesis, beyond the activation of B cells ( T cells in lupus patients have been correlated with abnormal mitochondrial hyperpolarization and adenosine triphosphate (ATP) depletion, which cause predisposition to death by necrosis ( + and CD8 + T cells that lack GPX4 would rapidly accumulate membrane lipid ROS, and undergo ferroptosis, leading to their inability to expand and protect against viral and parasite infections ( B cells are the central elements of humoral immunity and protection due to their ability to produce antibodies

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