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Materials and methods Bacterial strains The knockout strain of metZ gene (Rv0391) was generated in the genetic background of wild-type M

This process, called chelation, derives from the Greek word chele , meaning claw or pincer, illustrating EDTAs ability to effectively grasp and remove toxins

It requires: verifying the chemical compatibility between the peptides (cross-stability), optimizing the ratio to maintain the bioactivity of each component, individual quality control of each peptide before co-formulation, and validating the stability of the lyophilized mixture over time

Siddique S, Matera C, Radakovic ZS, Shamim Hasan M, Gutbrod P, Rozanska E, et al