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Nolan summarized the results of FLIES: 76% of those treated with the active intervention showed a reduction in areas of vitreous opacity, and approximately two-thirds of supplement users reported an increase in visual comfort

1 Introduction Liver diseases constitute a major and growing global health challenge, responsible for over 2 million deaths annuallyapproximately 4% of worldwide mortality (1)

doi: 10.3389/fvets.2025.1740059 Received 05 November 2025 Revised 26 November 2025 Accepted 11 December 2025 Published 07 January 2026 Volume 12 - 2025 Edited by Fan Yang, Henan University of Science and Technology, China Reviewed by Jiakang He, Guangxi University, China Runan Zuo, Anhui Agricultural University, China Updates Copyright 2026 Liu, Jiao, Xie, Ren, Lv, Du and Huang

doi: 10.1016/j.bbadis.2016.06.003 101 MesserJGKilbargerAKEriksonKMKippDE