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Recently, the Spanish group has shown that a good biochemical response to UDCA (defined by an alkaline phosphatase decrease greater than 40% of baseline values or to normal levels) within 1 year of starting treatment is associated with a similar survival to a matched Spanish control populations but this is not so for those patients who show no biochemical response following introduction of UDCA [107]

In contrast, rheumatoid arthritis is an autoimmune disorder that can cause chronic inflammation, potentially affecting multiple joints and leading to systemic symptoms

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Foods that are high in vitamin B12 include meat, fish, eggs, and dairy