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Finally, this relatively 'coarse-grained' mode of regulation is insufficient to precisely govern the bidirectional functions of ATF members or their heterodimeric interactions, limiting its ability to achieve fine-tuned control over their specific physiological and pathological activities

Thus, considerations of doseresponse relationships derived from epidemiologic studies concerning the health effects of arsenic in drinking water should include the likelihood that the dose derived from drinking water alone does not represent the total arsenic dose