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Tilney LG, Portnoy DA

Moreover, immune system-based approaches remove senescent cells by an inflammatory response, which could be problematic in the context of AD where neuroinflammation is present

In this review, we discuss how the neonatal Fc receptor (FcRn) acts as a regulator of the high levels of not only IgG Abs, but also albumin, by rescuing both these soluble proteins from cellular catabolism, and how a molecular and cellular understanding of this complex biology has spurred an intense interest in the development of FcRn-targeting strategies for the treatment of IgG-driven autoimmune diseases

On the other hand, diets high in processed foods and sugars may deplete glutathione levels, reducing its effectiveness