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S16, HT22 cells treated with A 142 exhibited a significantly higher proportion of JC1 monomers (green fluorescence) and a markedly lower proportion of JC1 aggregates (red fluorescence) than the negative control, indicating a decrease in mitochondrial membrane potential due to mitochondrial dysfunction

Furthermore, low doses of ionizing radiation induce antioxidant protective mechanisms through modulation of various antioxidant levels such as GSH and SOD, increasing anti-cancer activity, enhancing p53-related apoptosis of destroyed cells and precancerous cells apoptosis through reactive oxygen species (ROS)/reactive nitrogen species (RNS) and cytokine signaling, as well as inhibiting inflammation disease [94]

ChiE showed a dose-dependent inhibition of the CP and LP at 2 M and 4 M, respectively (Fig

[DOI] [PubMed] [Google Scholar] 12.Yong HY, Koh MS, Moon A