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Ascorbate and glutathione can individually participate in ROS detoxification operations, but their essential role results from their association in the context of the ascorbate-glutathione cycle (AGC), also called the Halliwell-Asada-Foyer cycle, after the scientists who identified it (see Focus on Hydroperoxide detoxification)

It has also been found that mice fed an HFD were generally characterized by lower total and reduced glutathione concentrations than those fed a standard diet [67]