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10.1179/1351000211y.0000000015 Redox Rep

increased glucose metabolism, decreased antioxidant enzyme capacity, protein kinase C (PKC) activation, irreversible protein glycation, AGE formation and an imbalance between ROS formation and elimination resulting in oxidative stress [20]

FMN (Flavin Mononucleotide) - Riboflavin-derived cofactor that helps enzymes move electrons

To avoid over interpretation of preclinical data, we emphasize the need for rigorous reverse translation: validating mechanistic hypotheses from animal models in human biospecimens