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GST catalyzes the conjugation of reactive metabolites, such as phosphoramide mustard, into less toxic compounds like 4-glutathionyl-cyclophosphamide ( GST genes variants associated with occurrence of adverse effects-related to CYC are GSTM1 , GSTP1 and GSTT1 ( GSTA1 is not included in this discussion, as its polymorphisms have been reported to influence the efficacy of CYC treatment rather than its toxicity or adverse effects ( GSTM1 gene encodes Glutathione S-transferase Mu 1 (GSTM1), a key phase II detoxification enzyme that catalyzes the conjugation of glutathione to electrophilic compounds, including toxic metabolites of cyclophosphamide such as acrolein and phosphoramide mustard ( GSTM1 null genotype is the common polymorphism in GSTM1

Postconditioning with irisin attenuates lung ischemia/reperfusion injury by suppressing ferroptosis via induction of the Nrf2/HO-1 signal Axis

(2010) Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts, J

Notably, the sensitivity of tumor cells and CTLs to ferroptosis in the TME remains controversial