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at the same time, Schwann cell autophagy is inhibited, leading to ROS accumulation, which activates the NLRP3/ASC/caspase-1 inflammasome, driving the production of mature IL-1 and IL-18 (Cheng et al., 2020

Low methionine ingestion by rats extends life span

It also inhibits the aggregation of amyloidbeta (A) peptides and hyperphosphorylated tau proteinhallmarks of ADby modulating kinases like GSK3, thus preventing plaque and tangle formation (Rahul and Siddique 2021)