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Moreover, the engagement of the sympathetic nervous system, in other words, the fight-or-flight mechanism, irrespective of the underlying trigger, is also almost always accompanied by a reduction in fat utilization and an increase in carbohydrate metabolism

There were a total of six double-blind placebo-controlled human clinical trials done spanning a total of ~900 clinically obese subjects between 2001 and 2006

Alternating between these approaches provides continuous fat loss support while respecting the need for receptor recovery