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Clinical markers of progression Older age, male sex, higher baseline motor scores and worse baseline cognition have all been linked to worse motor and cognitive outcomes at longitudinal follow-up 141,182,194,195,196 and have been integrated with sleep disorder, presence of depression and various genetic, imaging or CSF biomarkers into clinical predictive scores 182,196

In a safety and efficacy study, vinorelbine was proven as a good alternative for chemotherapeutic agents in age-enervated patients

Neurodegener Dis 11:4248 Forsberg E, Xu C, Grunler J et al (2015) Coenzyme Q10 and oxidative stress, the association with peripheral sensory neuropathy and cardiovascular disease in type 2 diabetes mellitus

Szeto B, Valentini C, Lalwani AK