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Relationship between plasma homocysteine and vitamin status in the Framingham study population

For an older person on vitamin B12 injections, once the blood level of vitamin B12 has normalized, the injections can be given once a month

Most patients resume routine activities

Higher-Caution Situations Extra medical supervision is important if you: have a history of reactions to injectable vitamins/cobalamins have significant kidney or liver disease are pregnant or breastfeeding are offered a compounded MIC B12 product without clear labeling of ingredients, concentrations, and compounding source The FDAs overview of compounding helps explain why quality can vary (see Compounding and the FDA: Questions and Answers )