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Like normal HSCs, LSCs reside in the BM niche of AML patients (23) which supports their survival and protects them against chemotherapeutic drug treatment (2426)

Chan NC, Salazar AM, Pham AH, et al

Indeed, the W34A mutation, which disrupts the ability of WW domain bind to a pSer/Thr-Pro motif 44 , prevented the PIN1 interaction with CDH1-WT (Supplementary Fig

Shacter E, Williams JA, Lim M, Levine RL (1994) Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay