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Despite their benefits, these drugs provide only symptomatic relief and do not directly address the underlying mechanisms driving AD pathology, highlighting an urgent need for novel therapeutic strategies (Passeri et al., 2022)

The uptake and metabolism of glutamine is elevated in LPS-activated M1 macrophages, and the replenishment of -KG by glutamine metabolism further promotes the accumulation of succinate, improving the stability of HIF-1, which in turn drives the production of pro-inflammatory cytokines (such as IL-1) [95, 96]