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Association of macular corneal dystrophy with excessive cell senescence and apoptosis induced by the novel mutant CHST6

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74 Apart from tumors with mutant IDH1/2, increased 2-HG have also been reported in breast cancer 75 and renal cancer (L-enantiomer), 76 which is associated with activation of MYC and L-2-hydroxyglutarate dehydrogenase (L2HGDG) deficiency, respectively