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Among these, proinflammatory cytokines such as interleukin (IL)-1 have been extensively studied in the context of OA

In dendrites of cortical pyramidal neurons lacking a novel MAM protein PDZ domain-containing protein 8, a significant fraction of Ca 2+ released from the ER during synaptic stimulation accumulates in the cytosol and elevates the local dendritic Ca 2+ levels

More specifically, the present invention relates to compositions and methods for treating and/or preventing and/or ameliorating symptoms of ASD and/or managing autism and related conditions