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The dataset contains 19,173,961 SNPs(The dataset is publicly available at the Google Cloud Storage location gs: 2.7 Statistical analysis Statistical analyses were conducted using R version 4.3.1 and software packages TwoSampleMR, MRPRESSO, and meta. The Inverse Variance Weighted (IVW) approach was used as the primary analytical method for MR to investigate the causal relationship between genetic variants associated with exposures and the outcome ( p -value 0.05 indicating heterogeneity and requiring the adoption of a Random Effects IVW method

Regardless, it is still unknown whether folate synthesized by the human colonic microbiota can substantially affect the bodys general folate status as this has never been sufficiently quantified to date 90,211,233,248,251,277,286,291

PubChem CID: 950107

The data is striking: in a Phase 2 trial published in the New England Journal of Medicine, the highest doses produced an average ~24% body-weight reduction at 11 months more than any currently approved weight-loss drug (American Diabetes Association)