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[DOI] [PubMed] [Google Scholar] 82

however, a prefacing discussion of the amphiphilic nature of LCACs and their membrane perturbing effects is necessary

To a stirred solution of 3-(3-(difluoromethoxy)phenyl)-1,5,6,7-tetrahydropyrano[3,2-c]pyrazole-6-carboxylic acid (24 mg, 0.08 mmol), HATU (32.4 mg, 0.09 mmol), and 3-amino-3-methyltetrahydrothiophene 1,1-dioxide (12.7 mg, 0.09 mmol) in DMF (387 l) was added DIPEA (40.5 l, 0.23 mmol)

[5] Following 4-weeks of maintenance therapy of 1500 mg daily, patients receiving immediate release niacin averaged 8.6 flushing events compared to 1.9 events in the Niaspan group